Daniel Walker has survived flesh-eating monsters and the Turpin's Tilt, but his most terrifying trial awaits at the end of Route 66.

Hunted and exhausted, Daniel fights his way through the desolate ruins of the Midwest to rescue young Beth from the clutches of the sinister Telos Institute. The hot trail leads his scattered group of survivors to Patch, a walled safe-zone where the illusion of a peaceful society masks a dark conspiracy.

Pursued by bio-engineered Flesh monsters and caught in a treacherous three-way war between resistance fighters, extremist cults and the ruthless Telos Military Division, Daniel is pushed to his absolute psychological limits. Forced to rely on manipulative magicians, unstable allies and a blonde enigma, he takes on more brutal responsibility than his fractured psyche can handle. Will Daniel cross his darkest moral boundaries to save the people he loves? Or will the relentless nightmare of the apocalypse finally strip away his humanity forever?